4 replies to this topic

[fishinghat]

The following article discusses the clinical trials of an arthritis drug (remdesivir) for treating coronavirus patients. This drug has a pronounced effect on interleukin 6 which the virus stimulates the production of and which causes all the fluid to build up in the lungs and drown the patient. The Manufacturer gave a press conference this morning stating that initial results are very promising in helping the patients better recover from the virus. While this drug is not approved for use on viruses it is being used in this clinical trial on what is called the "compassionate care" usage. Basically it can be given to patients that doctors believe will not recover from the virus so this drug can be used in a desperate effort to help the patients.

https://www.nature.c...1422-020-0282-0
https://www.ncbi.nlm...les/PMC7054408/
https://www.newsweek...ovid-19-1491292

[invalidusername]

Good find Hat - top two are same publication, and conclusion states;

 

"Our findings reveal that remdesivir and chloroquine are highly effective in the control of 2019-nCoV infection in vitro... [we] suggest that they should be assessed in human patients suffering from the novel coronavirus disease."

 

But as the newsweek link states, the virus spreads quicker than the vaccine... isn't that always the way. Also, nice typo of "FAD-approved meds" mid-point in the article!!

 

However, given the history, it should have been given a priority as the article also states;

 

"After three coronavirus outbreaks in 20 years—severe acute respiratory syndrome, Middle East respiratory syndrome and now SARS-CoV-2—it's an investment that needs to be made."

[invalidusername]

Follow-up to that above...

 

"[according] to the director of the U.S. Centers for Disease Control and Prevention (CDC), Robert Redfield, remdesivir is already being given to COVID-19 patients. The U.S. Food and Drug Administration allows patients in the U.S. to use unapproved drugs in "life-threatening" situations when there are no other options, which explains why COVID-19 patients are permitted to take remdesivir."

 

Source: https://www.nasdaq.c...ents-2020-03-12

[fishinghat]

The biggest point I took out of this was from the press conference this morning saying that the preliminary tests (Phase 3) on remdesivir are very promising.

IUN - Those life threatening situations are the ones I mentioned in the "Compassionate Care" scenario. That kind of use has been allowed, by regulation, for many decades especially in advanced cancer patients.

[fishinghat]

I must do a correction here. Remdesivir was developed to fight other types of coronavirus like IUN referenced. The arthritis drug I was thinking of is Piclidenoson. It is also in phase 3 trials. As of yet I have seen no results from the clinical studies. This drug has a pronounced effect on interleukin 6 which the virus stimulates the production of and which causes all the fluid to build up in the lungs and drown the patient. I will keep everyone posted.

Sorry for the misleading information.