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Going Cold Turkey With Sertraline?


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#181 fishinghat

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Posted 28 December 2018 - 05:32 PM

A chronic adrenergic state is the most common condition that exists in any withdrawal. The length of time is dependent on the length of withdrawal. Normally 6 to 8 months after your last dose. This does vary a lot. When I decided to cross over to Zoloft after going through 9 months of withdrawal I had to work up to 150 mg to off set the withdrawal. Each increase in dose helped a little bit more. Having said that I know many members that only had to take 25 or 50 mg to get the bulk of their symptoms under control. For some of them relief came in a matter of days and many were like me it took effect slowly over a one month period. The point being that there is no answer to how long. Sorry.

 

The heart pounding and racing heart can be dealt with using atenolol but it will have little help with the emotional issues. Clonidine will help with both and hydroxyzine with the anxiety.

 

Have you tried some of the items in that document that others have tried. Like Zantac, diphenhydramine, melatonin etc. These are over the counter drugs and may help. It may noy cure you but at least take some of the edge off.


#182 fishinghat

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Posted 28 December 2018 - 05:42 PM

Here are some other things that may help.

Pseudoephedrine/Phenylephrine containing meds
Used to treat nearly all withdrawal symptoms.
Caution - Pseudoephedrine can raise blood pressure and cause nervousness in some people.
Pseudoephedrine is an agonist at both alpha- and, to a lesser degree, beta-adrenergic receptors.
Johnnyz - earlier today I read a topic in here about pseudoephedrine and its supposed effectiveness to alleviate SSRI withdrawal symptoms. I take 12-hour sudafed (the real, behind the counter sudafed) 1-2x daily as I have persistent nasal congestion. Yesterday evening, soon after the morning sudafed tab had worn off, I had a very stressful situation which caused an emotional low that had me sitting for 10 minutes feeling very depressed. I was able to talk myself out of that stupor and continue on in a neutrally emotional state until bedtime. I took a 12-hr sudafed around 11pm and woke up at 6am this morning feeling very good physically and emotionally,
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Bragg's Apple Cider Vinegar
Another "home remedy" that really helped me (still does, I'm still taking it) is Bragg's Apple Cider Vinegar ... it's also available in most health food stores, as well as from the internet (Amazon, and Bragg's directly) ... can be put in water, with honey, etc.... during early withdrawal, I drank it straight ... my food cravings were totally weird, and at the time it actually tasted great just like that ... blech ... there've been studies (which I now can't find, typical) that indicate it's a food that naturally increases serotonin levels ... it also cured my arthritis ... (Grandma knew more than I gave her credit for!)
The Bragg's ACV, which is unpasteurized and has what they call the "mother" in it...weird term, but that's the stuff that would otherwise be pasteurized out ....what starts to form when apple cider begins to go "hard" ....

Lady Nancy - I could not resist the urge to search and found several references to Bragg's Apple Cider Vinegar which is an unfiltered and unpasteurized apple cider vinegar. Many are unable to take it due to stomach issues in which case a good alternative is Malic Acid/Magnesium in pill form as it works the same.
Serotonin/tryptophan connection mentioned . . .
http://health.usnews...e-cider-vinegar

This is an interesting discussion about ACV from the Social Anxiety Forum....
http://www.socialanx...a-relief-47323/
JBhibbard - Drink lots and lots of water. Have you tried the apple cider vinegar detox? I believe it helps.
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Melatonin
FH - a research article where it was shown that taking 3 mg of melatonin under the tongue (sublingual) helps with anxiety. Place it under the tongue until dissolved and gone. In case you are not familiar with melatonin it is the chemical your body produces in the evening to make you sleepy and ready for bed.
Several other areas mention melatonin. A search of this topic for the word Melatonin yeilds much more information.
https://www.ncbi.nlm...pubmed/15639542
it is suggested that melatonin exerts its analgesic actions not by binding to opioid receptor subtypes but by binding to its own receptors and increasing the release of beta-endorphin.
As well as ...
https://www.ncbi.nlm...pubmed/12579851
https://www.ncbi.nlm.../pubmed/3361078
https://www.ncbi.nlm.../pubmed/1668619
https://www.ncbi.nlm...les/PMC5038497/
and more.

Also....
https://www.ncbi.nlm...pubmed/12043836
Inhibition of dopamine release by melatonin has been demonstrated in specific areas of the mammalian central nervous system (hypothalamus, hippocampus, medulla-pons, and retina). Antidopaminergic activities of melatonin have been demonstrated in the striatum.

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#183 fishinghat

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Posted 28 December 2018 - 05:44 PM

Gatorade

Many members found Gatorade to be considerable help in fighting most withdrawal symptoms, especially the green gatorade.

watchdog - Drinks LOTS of GREEN gatorade..... don't know what the deal is, but it helps.
Gatorade Fierce Green Apple Sports Drink - This may be the "green gatorade" that members spoke of. It contains malic acid, the active ingredient in apple cider vinager which has proved so helpful to other members. Other ingredients are the same.

Isopure Zero Carbs - No sugar, with some calcium. Contains Malic acid
Isopure Mass - With sugar and proteins, with calcium, Contains Malic acid
Isopure zero carb with proteins - no sugar, contains proteins. With calcium Contains Malic acid
Sparkybird - I’ve found that Pur Aqua Sparkling Frost in any flavor has malic acid. I discovered it by accident. It is only 50 cents at Aldi’s. It is only 10 calories a bottle.
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NAC - N-acetylcysteine - Strong antioxidant.
https://www.ncbi.nlm...pubmed/18534556
NAC appears a safe and effective augmentation strategy for depressive symptoms in bipolar disorder.
https://www.ncbi.nlm...pubmed/25004186
the study provides only limited support for the role of NAC as a novel adjunctive therapy for MDD.
https://www.ncbi.nlm...pubmed/21719110
These open label data demonstrate a robust decrement in depression scores with NAC treatment
https://www.ncbi.nlm...pubmed/22891797
There were no significant between-group differences in recurrence or symptomatic outcomes during the maintenance phase of the trial;
https://www.ncbi.nlm...pubmed/27725170
The anxiolytic effects of NAC were comparable to diazepam.

Freeme - I have been taking milk thistle to detox the liver and zertex. I put benadryl spray on my arms at night. I am taking also x3 NAC which cleanses the liver too. These both will calm down my itchy to nothing.
3 members reported a positive experience with this product.
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Lion's Mane Mushroom
(AKA Yamabushitake or H. erinaceum )
Anxiety and Depressive symptoms have also been reduced in humans fed 2g of Yamabushitake, via cookies, over the course of 4 weeks. There was a significant difference between groups on the measurements of concentration and irritability, favoring the Yamabushitake group. Nagano M, et al. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. (2010)
Dosage
Dosing of Lion’s Mane Mushroom depends on the strength of the extract. It’s available in capsule or powder form.
For Lion’s Mane 10:1 extract (30% polysaccharide), daily dosage is 500 – 1,000 mg taken 1 to 3 times per day.
Other retail extract dosage of Lion’s Mane ranges from 300 mg to 3000 mg dosed 1 – 3 times per day. Check the label and see what the manufacturer recommends. And when first using the supplement, start with the lowest dose and see how your body reacts.
Start at 500 mg per day and see how it works for you. If you don’t experience a benefit, boost Lion’s Mane in small increments of 250 mg per day until you notice an improvement.
file:///C:/Users/Neil/AppData/Local/Microsoft/Windows/INetCache/IE/K78IEYPO/solid-state-cultivation-of-hericium-erinaceus-biomass-and-erinacine-a-production-2155-9821.1000210.pdf
Erinacine A, isolated from the cultured mycelia of H. erinaceum, the main representative of this compounds group, has a strong enhancing effect on NGF synthesis, much stronger than epinephrine. Furthermore, this compound increases catecholamine and NGF content in the central nervous system of rats.
Erinacines and hericenons reduce anxiety as well as depression. For an accurate understanding of the overall mechanism of H. erinaceus diterpenoids action it requires additional clinical studies with physiological markers, such as hormones, or more profounded studies of autonomic nervous activity
https://www.thefreel...on.-a0430893147
Summary of the antianxiety/antidepressive effects of components of H. erinaceus.

BK Yang et al., “Hypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus," Bioscience, Biotechnology, and Biochemistry, vol. 67, no. 6 (June 2003): 1292–1298.
A cell wall polysaccharide produced by a special, submerged culture of lion’s mane mushroom was found in an animal study to lower cholesterol by 32%, LDL cholesterol by 45.4%, and triglycerides by 34.3%, and to raise the “good” HDL cholesterol by 31%.9 The researchers proposed that the mushroom’s constituents helped to lower cholesterol production via the hepatic HMG-CoA reductase pathway, reducing the amount of this enzyme by 20%.
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#184 fishinghat

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Posted 28 December 2018 - 05:46 PM

Ashwagandha
(Withania somnifera )
https://www.ncbi.nlm...pubmed/25405876
All five studies concluded that WS intervention resulted in greater score improvements (significantly in most cases) than placebo in outcomes on anxiety or stress scales.
https://www.ncbi.nlm...pubmed/26068424
Our results provide evidence indicating that key constituents in WS may have an important role in the development of pharmacological treatments for neurological disorders associated with GABAergic signaling dysfunction such as general anxiety disorders, sleep disturbances, muscle spasms, and seizures.
https://www.ncbi.nlm...pubmed/19718255
300 mg twice a day.
Final BAI scores (anxiety test) decreased by 56.5% in the Ashwagandha group. Significant differences between groups were also observed in mental health, concentration, fatigue, social functioning, vitality, and overall quality of life with the Ashwagandha group exhibiting greater clinical benefit. No serious adverse reactions were observed in either group.

http://www.ncbi.nlm....pubmed/24497737
250 mg 2x/day

http://www.ncbi.nlm....pubmed/24330893
500 mg/day for bipolar, effective.

http://www.ncbi.nlm....pubmed/23439798
Each capsule contained 300 mg of high-concentration full-spectrum extract from the root of the Ashwagandha plant. Each person took 2 capsules a day. The treatment group that was given the high-concentration full-spectrum Ashwagandha root extract exhibited a significant reduction in scores on all the stress-assessment scales on Day 60, relative to the placebo group. The serum cortisol levels were substantially reduced in the Ashwagandha group, relative to the placebo group. No serious adverse events were reported.

http://www.ncbi.nlm....pubmed/22546655
W. somnifera extract is effective in treating obsessive compulsive disorder
https://www.ncbi.nlm...pubmed/18697607
The results suggest the protective effect of WS in the management of ethanol (alcohol)withdrawal reactions.

https://www.ncbi.nlm...pubmed/17585686
Preliminary results suggest that Withania root extract can be used in the management sleep loss and associated oxidative stress.

http://www.ncbi.nlm....pubmed/19363747
Effective for anxiety

http://www.ncbi.nlm....pubmed/11194174
WSG also exhibited an antidepressant effect, comparable with that induced by imipramine in the 'behavioural despair' and 'learned helplessness' tests. The investigations support the use of WS as a mood stabilizer in clinical conditions of anxiety and depression

http://www.ncbi.nlm....les/PMC3252722/
It has a Cognition Promoting Effect and was useful in children with memory deficit and in old age people loss of memory. It was also found useful in neurodegenerative diseases such as Parkinson's, Huntington's and Alzeimer's diseases. It has GABA mimetic effect and was shown to promote formation of dendrites. It has anxiolytic effect and improves energy levels and mitochondrial health. It is an anti-inflammatory and anti-arthritic agent and was found useful in clinical cases of Rheumatoid and Osteoarthritis.

http://www.ncbi.nlm....les/PMC3487234/
1,250 mg/day × 10 days
All volunteers tolerated WS without any adverse event.
Safety and side effects

http://www.ncbi.nlm....les/PMC2958355/
This product is comparative to lorazepam in its ability to control anxiety. That is impressive.
https://www.ncbi.nlm...les/PMC2958355/
250 mg twice a day.
At 6 weeks, significantly more patients met a priori response criteria in the drug group (88.2%) as compared with the placebo group (50%). The drug was well-tolerated and did not occasion more adverse effects than did placebo. It is concluded that this ethanolic extract of Withania somnifera has useful anxiolytic potential and merits further investigation.

https://www.ncbi.nlm...pubmed/28004351
This study provides scientific validation to the anxiolytic, anti-inflammatory and anti-apoptotic properties of ASH-WEX, which may serve as an effective dietary supplement for management of SD induced stress and associated functional impairments.

Members Comments
One member reported taking it during withdrawal and said it was very beneficial.
Brz - ashwagandha update:
had to stop - bummer.
definitely allergic. just like sk8ermama. i couldn't figure out why my allergies hadn't gone away even after the pollen count dropped way down. stopped the ashwagandha and my congestion and headaches subsided. not to mention i had a very tight chest feeling. very uncomfortable. my side effects are not uncommon from what i've learned. i may try again way down the road but now that i'm battling reflux, i don't want to complicate things. i've heard rhodiola is a similar adaptogen, but don't want to introduce anything new into my system right now.
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Vitamin C (ascorbic acid ) is a cofactor in at least eight enzyme reactions reactions, including several collogen synthesis reactions that, when dysfunctional, cause the most severe symptoms of scurvey. In animals, these reactions are especially important in wound-healing and in preventing bleeding from capillaries. Vitamin C may also act as an antioxidant against oxidative stress. The functions of Vitamin C include the synthesis of collogen, carnitine, and neurotransmitters (norepinephrine from dopamine) the synthesis and catabolism of tyrosine; and the metabolism of microsome. RDA is 75 to 90 mg/day with no more than 2000 mg/day maximum. The signs and symptoms of overdose is nausea, vomiting, diarrhea, flushing of the face, headache, fatigue and disturbed sleep. Vitamin C's anxiolytic properties is beleived to primarily be from its ability to repair oxidative effects from stress.
http://www.ncbi.nlm....pubmed/24511708
Effective at 1000 mg/day
http://www.ncbi.nlm....les/PMC2885294/
Effective
https://www.ncbi.nlm...pubmed/24979594
Effective
https://www.ncbi.nlm...pubmed/21036190
Effective and lowers cortisol levels.
https://www.ncbi.nlm...les/PMC2649700/
Ascorbate is proposed as a neuromodulator of glutamatergic, dopaminergic, cholinergic and GABAergic transmission and related behaviors.
https://www.ncbi.nlm...les/PMC3964749/
A paper explaining the relationship between oxidative stress and anxiety.
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L-theanine
Research
The research shows that all green tea leaves contain both L-theanine and D- theanine BUT only the special processing used by the manufacturer produces pure L-Theanine and is the choice of many of the research biologists.

https://www.ncbi.nlm...pubmed/22214254
https://www.ncbi.nlm...pubmed/16759779
https://www.ncbi.nlm...pubmed/14755608

Rapid Commun Mass Spectrom. 2004;18(3):251-6.
Analysis of derivatized and underivatized theanine enantiomers by high-performance liquid chromatography/atmospheric pressure ionization-mass spectrometry.
Five of the six products contained significant amounts of D-theanine. Only one product, SunTheanine, appeared to contain only the L-theanine enantiomer.

https://www.ncbi.nlm...les/PMC3049752/
Note - Suntheanine is the pure ingredient and that is what you want. That is the pure L-theanine. D-theanine is not absorbed by our bodies.
L-theanine is an amino acid precursor to glutamate and glutamine.

Key Points
It can cross the blood brain barrier. It is only produced by plants and fungi. It inhibits glutamine transporters and glutamate transporters, and thus blocks the reuptake of glutamine and glutamate. Theanine increases serotonin, dopamine, GABA, and glycine levels in various areas of the brain. Caution – Most plants that contain L-theanine also contain caffeine and it can be a significant contaminant in L-theanine supplements.Theanine has been studied for its potential ability to reduce mental and physical stress, improve cognition, and boost mood and cognitive performance in combination with caffeine. In combination with caffeine it may increase anxiety.
Scientific Information
A National Standard monograph that reviews current research on theanine reports that it is likely safe in doses of 200–250 mg up to a maximum daily dose of 1,200 mg. Theanine is used to help with anxiety, blood pressure control, mood, and cognition. Natural Standard rates the evidence to support the usage for anxiety, blood pressure control, and mood as “unclear or conflicting scientific evidence” and the evidence for cognition as “fair negative scientific evidence.” Many of the studies of theanine were done in combination with caffeine as found in tea. While the studies found that the combination had some effect on mood, the studies found that theanine alone had little effect. More sufficiently designed studies in humans are warranted to further our understanding of the effects of theanine.

https://www.ncbi.nlm...pubmed/21208586
Effective, 400 mg/day
https://www.ncbi.nlm...pubmed/15378679
Not effective on anxiety, 200 mg/day
https://www.ncbi.nlm...les/PMC4137547/
Used to treat PTSD. It was successful in treating 8 gene problems associated with PSTD in the hippocampus and amygdala.

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#185 fishinghat

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Posted 28 December 2018 - 05:49 PM

Acupuncture
https://www.ncbi.nlm...pubmed/22073885
https://www.ncbi.nlm...pubmed/22073888
https://www.ncbi.nlm...pubmed/24215920
https://www.ncbi.nlm...pubmed/26896946
https://www.ncbi.nlm...pubmed/25595195
https://www.ncbi.nlm.../pubmed/7455665
and more
Member comments and tips - 15 reviews 14 positive.
FH - Many of my friends and family members have had acupuncture over the years. I think it is a great tool BUT there are a lot more idiots doing acupuncture than experts. In fact my family has only found one so far in the states that new what he was doing (I am sure there are others though).
Traceyish - I've been trying acupuncture, and a host of natural remedies but nothing is working.
GMI - I found a lot of relief from acupuncture in the early stages of withdrawal. I’ve mentioned in prior posts that I was never one to believe in acupuncture even though so many people have told me what wonders it's done for them. These types of acupuncture facilities are all over the country and one near you can be found on this link if you’re is interested in giving it a try: https://www.pocacoop...earch-by-state/
Zeus - However, my general practitioner thought different. She uses a combination of eastern and western medicine and suggested acupuncture. Wow what an improvement. I had one treatment this morning and no nausea since. Even the fatigue is better and I feel like eating again.
considering - Check out the U.S. network of Community Acupuncture Clinics. They are a great way to get low cost acupuncture treatment.
BCH - I used acupuncture, which helped amazingly well. Over a period of about 4 months I suffered very few side effect.
ECU - the auriculotherapy (like acupuncture, only done on the ear alone) was based on a 5 point protocol designed to treat heroin addicts in withdrawal, and got rid of all the physical symptoms (temporarily) and enabled me to function while my body adjusted.
cmonk - I had been going for acupuncture treatments and yes they are wonderful
Sarahj - Oh yeah, I realized how much acupuncture was helping me after the third treatment, I went once a week. So, I hope that it provides some benefit to you. One thing that I tried during the worst of the withdrawal is acupuncture. It really made a difference in my overall outlook on everything, not in a magic bullet kind of way, but my sense of being aware and wanting to take better care of myself seem to be heightened by the experience.
Rogerwilco -Acupuncture is definitely the best way I've found to treat withdrawal discomfort from pharma drugs. The thing about acupuncture is that it has side effects too... but they're all GOOD! I mean, like, WOW :!:
Ramona - acupuncture regularly now. It doesn't take away all the withdrawal symptoms, but it balances the systems in your body to help you feel better while you're going through this. Really calms down the anxiety, quiets your mind.
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Deep breathing, sighs, yawns....
These activities cause an increase in the release of dopamine, endorphons and serotonin. This fact has been used by psychologists for decades to help control anxiety, depression and sleep. By causing yourself to yawn several time over a 10 or 15 minute period it will release enough of these neurotransmitters to help relax and induce sleep. Sighs work much in the same fashion bugt to a lesser degree, Breathing exercises are the most effective. A good psychologist should be used to teach the most effective techniques.
https://www.ncbi.nlm.../pubmed/9551709
Member comments and tips -
deep breathes, breath(ing) - 22 comments all positive
Raven - Breathe it deep calming breaths and hold them for about 5 seconds before slowly letting them out.
Gail - you need to breathe, yes breathe in and out slowly.
FH - Deep breathing. Close your eyes—and try taking deep, slow breaths— making each breath even deeper than the last. If you have a psychologist who could teach you relaxation techniques, controlled breathing and heart rate, etc. These techniques really do work.
Raven - Just do you best to stay calm and use breathing techniques. My husband and FH have given me great tips on breathing when anxiety strikes. FH because he is a veteran and my husband because he has asthma.
Keys to breathing:
** Take slow deep breaths (breath in deeply and slowly)
** Hold for at least 15 secs if you can
** Exhale slowly
***repeat as needed*

FN - What helped me the most with this was yoga ...the breathing exercises ... once learned, they can be done anywhere, anytime .... the release of the built up anxiety in my body was tremendous ...
Janson - . i've learned a few breathing exercises via yoga and that helps immensely to calm down those nerves that are about to snap. even without knowledge of specific breathing exercises, just take deep full breaths with hands on your stomach and see your tummy rise on the breath in and then fully breath out. so simple, so effective.
Note - There must have been well over 100 members that had posts similar to the one below. Shortness of breath, heart pounding, skip beats, tightness in the chest or chest pain. hese are classic anxiety symptoms and are the result of elevated adrenalin e levels. Adrenaline is a vasoconstrictor and bronchiole constrictor. These shallow rapid breaths allow CO2 to build in the lungs and worsens the symotoms. Alpha-agonists (eg. clonidine) and beta blockers (atenolol) work well t o block the effets of this excess adrenaline. Breathing exercises also help considerably in breaking this Cycle. As you can see below ZA got it really right.
Snap87 - Just scared with the shortness of breath and heart palpitations more than anything.
ZA - the 'out of breath' symptom is actually shallow breathing and I had that for about 2days it is very exhausting as it causes your ozygen saturation to drop. what worked for me 'was awareness -slow deep breathing -then a little aerobics. it helped to up my b/p and neuteralize by blood gases.
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Conditioned Response -
One of the methods that can have a dramatic effect on anxiety is the development of a phrase in association with breathing exercises and relaxation techniques. This usually takes time to develop but is very effective. The process is begun by selecting a phrase...say the word "easy" for example. When you notice that you begin to get too anxious then lay down, close your eyes and begin your deep breathing exercises while also doing relaxation like 'progressive relaxatiion' all the time repeating the word 'easy' in your mind. With practice this becomes very effective and the need to lay down to acheive success is not necessary. You simply stop in place, close your eyes and say the word 'easy" to yourself while relaxing and breathing deeply. You then prodeed on with your activities. This can be further used by your spouse to help you control your anxiety. If your spouse notices you becoming anxious they can simply develop a certain place she/he touches you gently as a signal that you need to stop, breath and relax. With practise this becomes automatic and can easily be done in public without drawing attention to your state of mind. The is a conditioned response so it MUST be practised until it is a reflex action to be most helpful.
Three members report using this technique with excellant results.
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#186 fishinghat

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Posted 28 December 2018 - 05:51 PM

Increasing Dopamine Levels
Summary;
⦁ The cycle is: tyrosine converts to L-Dopa to dopamine to norepinephrine and then epinephrine. Therefore caution should be used when trying to raise dopamine to treat depressison. Begin with small doses until releif is obtained. Do not take larger doses as any extra unused dopamine will be changed to noradrenaline and adrenaline and the result could be anxiety.
⦁ An overabundance of bad bacteria in the GI system leaves toxic byproducts called lipopolysaccharides which destroy the brain cells that make dopamine. Therefore a good probiotic should be used.
⦁ And don’t reach for artificial sweeteners. Aspartame decreases brain levels of both dopamine and serotonin, another important mood-boosting neurotransmitter.
⦁ L-tyrosine is the first dopamine supplement to consider. L-tyrosine and phenylalanine compete with tryptophan for absorption. Tryptophan is converted to serotonin by the body so if too much L-tyrisine is present n the blood stream then serotonin levels may decrease.
Increase Dopamine with Meditation
The benefits of meditation have been proven in over 1,000 studies. Regular meditators experience an enhanced ability to learn, increased creativity, and deep relaxation. It’s been shown that meditation increases dopamine, improving focus and concentration. Creative hobbies of all kinds, including knitting, quilting, sewing, drawing, photography, woodworking, and home repair, bring the brain into a meditative state. These activities increase dopamine, ward off depression, and protect against brain aging.
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Check Sodium, Calcium and Magnesium levels as well as estrogen and testosterone levels. You would not imagine how many members found problems with one or more of these issues during withdrawal.
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Repetitive Transcranial Magnetic Stimulation (rTMS).

Transcranial magnetic stimulation (TMS) is a method in which a changing magnetic field is used to cause electric current to flow in a small region of the brain via electromagnetic induction. During a TMS procedure, a magnetic field generator, or "coil", is placed near the head of the person receiving the treatment. The coil is connected to a pulse generator, or stimulator, that delivers a changing electric current to the coil
Wiki

Anxiety

Left DLPFC rTMS stimulation reduced the anxiety bias effect or how to restore the positive memory processing in high-anxiety subjects.
Reduced anxiety

https://www.ncbi.nlm...pubmed/24081515
[Repetitive transcranial magnetic stimulation (rTMS) for anxiety disorders--a possible therapeutic option?].
Beneficial

https://www.ncbi.nlm...pubmed/25659132
Repetitive transcranial magnetic stimulation ameliorates anxiety-like behavior and impaired sensorimotor gating in a rat model of post-traumatic stress disorder.
Helped

https://www.ncbi.nlm...pubmed/24278088
Repetitive Transcranial Magnetic Stimulation (rTMS) to Treat Social Anxiety Disorder: Case Reports and a Review of the Literature.
Helped

https://www.ncbi.nlm...pubmed/22528734
rTMS stimulation on left DLPFC affects emotional cue retrieval as a function of anxiety level and gender.
Helped

https://www.ncbi.nlm...pubmed/20599325
Baseline 'state anxiety' influences HPA-axis sensitivity to one sham-controlled HF-rTMS session applied to the right dorsolateral prefrontal cortex.
Inconclusive

https://www.ncbi.nlm...pubmed/21631403
The value of repetitive transcranial magnetic stimulation (rTMS) for the treatment of anxiety disorders: an integrative review.
No conclusive evidence it helps.

https://www.ncbi.nlm...pubmed/24923343
Repetitive transcranial magnetic stimulation (rTMS) to treat refractory panic disorder patient: a case report.
Helped

https://www.ncbi.nlm...pubmed/23683151
Repeated transcranial magnetic stimulation on dorsolateral prefrontal cortex improves performance in emotional memory retrieval as a function of level of anxiety and stimulus valence.
"might limit" anxiety

https://www.ncbi.nlm...pubmed/24757668
Does rTMS alter neurocognitive functioning in patients with panic disorder/agoraphobia? An fNIRS-based investigation of prefrontal activation during a cognitive task and its modulation via sham-controlled rTMS.
No benefit

https://www.ncbi.nlm...pubmed/26843373
Better than treated as usual: Transcranial magnetic stimulation augmentation in selective serotonin reuptake inhibitor-refractory obsessive-compulsive disorder, mini-review and pilot open-label trial.
2/3 of current ssri treated group showed further improvement.

https://www.ncbi.nlm...pubmed/25565694
Repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex for treating posttraumatic stress disorder: an exploratory meta-analysis of randomized, double-blind and sham-controlled trials.
"seems to be effective and acceptable for treating PTSD"

https://www.ncbi.nlm...pubmed/18572984
A preliminary study of fMRI-guided rTMS in the treatment of generalized anxiety disorder.
Effective

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#187 fishinghat

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Posted 28 December 2018 - 05:53 PM

Neurofeedback
Neurofeedback (NFB), also called neurotherapy or neurobiofeedback, is a type of biofeedback that uses real-time displays of brain activity—most commonly electroencephalography (EEG), to teach self-regulation of brain function. Typically, sensors are placed on the scalp to measure activity, with measurements displayed using video displays or sound.
Juli - when i reinstated from cold turkey but was feeling like crap for 8 weeks i started neurofeedback and it really helped. it seemed to get my brain back on track and helped with the nausea and anxiety. might be worth a try.
ThisMoment - Taking your temperature with a thermometer is a form of biofeedback. You can listen to your heartbeat via a stethoscope and actually cause it to slow down- that's an example of neurofeedback.
Neurofeedback or neurobiofeedback- There is a "normal" pattern of brain activity for a person's gender and age. There are a number of different EEG brain signatures for depression, ADD, and anxiety (for example), and your EEG is compared to those-- this is called a Quantitative Electroencephalogram or QEEG. Then it's determined what type of neurofeedback therapy would benefit you most. You are hooked up to the machine via scalp probes, and on a screen you view brainwave representative patterns with which you interface and alter directly. Do it enough (practice) and your brain changes.
This technology has supporters and critics. I don't know enough about it to offer criticism of the service, but I do think that when you include the whole body and all of your senses in real situations when training your brain, the result is always authentic, profound, and long-lasting.
Xanaxul - This is basically what neurofeedback does: to use the "gates" to our brain, that our senses are, to try the reshaping of discrete regions thus "normalizing" brain functions.
In my opinion, despite the "scientific apparel" it is clothed (EEG responses to the positive or negative stimuli, pinpointing of the brain areas...) it has not much advantages, over any other empirical methods (including the century old ones) that may be used to influence brainwave entrainment, brain connections reshaping or the volume and density of brain areas involved in cognition, mood and emotion processing.

But again, this is just my opinion.

We know so little about how our brain works, that I guess for the moment: "if it makes you feel better do it" has to be the motto.

ThisMoment - Here's a concern: The process of discontinuation will change your brain, and some of the progress achieved via the neurofeedback may be lost (or irrelevant) due to the changing landscape of your brain. Perhaps consider reducing or stopping the neurofeedback sessions until you are free and clear of the re-construction project in your brain. Then go back in with a more stable platform.

Greenpurple - You are right- Neurofeedback is so expensive! I am blessed to be able to afford some of it. And so is Cymbalta/Duloxetine. No wonder folks are so mad!!

Now that I've begun the neurofeedback road, I am so excited to see what is possible getting off my medsor reducing. I'm curious if I've been experiencing some of the side effects you all have been experiencing without knowing it. I've already forked out quite a bit of money (inheritance) and so can't afford unlimited neurofeedback but want to go off Cymbalta sloooooooowly, like everyone here has recommended. I went down from 90
To 60mg, no prob. Then started pellet counting as so many have recommended. I've cut down 10% each month (very sloooowwwww). Now I am down to 153 pellets and am quite proud of that! And I'm feeling great.

I think I may be cutting down too slowly if I am doing neurofeedback. At this rate, it would take me 360 more sessions (neurofeedback 2x per week and cutting 10% each month)!!!! That is absolutely impossible financially. Even twice as fast isn't a possibility (180 sessions)!

Does anyone have an idea how quickly I could cut down with minimal withdrawals while doing neurofeedback???

Geff - I have to say the Neurofeedback made a HUGE change in my outlook! I am FINALLY able to concentrate and focus (which is important as I'm a computer programmer).

Just in case you (or anyone else reading your blog) isn't familiar with Neurofeedback, here's a quick description:

My therapist hooks up some sensors to my head and a computer program reads the electrical signals my brain is producing. It does NOT send any signals, shocks, etc.... just reads what my brain is doing. When my brain produces signals that are good, the computer goes *BING*. I guess my brain likes that because it starts trying to make it go *BING* more. The end result is that my brain is "trained" to work the way it should.
It was so cool the first session when she hooked me up and told me what she was seeing (I have a screen, too, to see what the program is reading). She was able to compare my brain activity to that of a "normal" brain and describe why I felt so down and had so much trouble focusing.
The only side-effects I've had are:
1. a very slight headache that goes away shortly after the treatment
2. better mood
3. better concentration
4. better productivity

Juli - I just wanted to add that I found neurofeedback to be super helpful when I was going through withdrawl. I went twice a week and it kind of "fixed my brain" a bit and helped a lot with the anxiety. I ended up needing 28 sessions.


Biofeedback

Guest_crushynn - A couple weeks after starting Cymbalta I started seeing a nutritionist & biofeedback person which has helped me soooo much as far as energy, focus, digestion, mood & weight. I noticed the Cymbalta wasn't working as well after a couple months & since I was doing so well with biofeedback & supplements, I decided to wean off Cymbalta about 3 weeks ago. I was only taking 30mg/ day to begin with so the withdrawals are amazing to me.

Imdone - In the meanwhile, consider meditation to give you control over anxiety. Biofeedback (covered by insurance) is another way to control anxiety.

Research

https://www.ncbi.nlm...pubmed/29432505
Psychiatr Pol. 2017 Dec 30;51(6):1095-1106. doi: 10.12740/PP/68919. Epub 2017 Dec 30.
The use of EEG Biofeedback/Neurofeedback in psychiatric rehabilitation.
Its psychiatric applications for clinically diagnosed disorders include treatmentof depression, anorexia, dyslexia, dysgraphia, ADD, ADHD, schizophrenia, abuse of substances, neuroses, PTSD, and Alzheimer's disease. Research results imply that the neuromodulating effect of the therapy positively influences cognitive processes, mood, and anxiety levels. Positive effects of EEG Biofeedback confirm usefulness of this method as a main or auxiliary method in treatment of people with mental disorders. On the basis of conducted studies, it is worthwhile to consider inclusion of this method into the comprehensive neurorehabilitation activities.

https://www.ncbi.nlm...pubmed/28236680
Behav Res Ther. 2017 May;92:32-40. doi: 10.1016/j.brat.2017.02.002. Epub 2017 Feb 20.
Frontal alpha asymmetry neurofeedback for the reduction of negative affect and anxiety.
The asymmetry group showed an increase in alpha asymmetry driven by higher alpha at the right site (p < 0.001), as well as a coherent reduction in both negative affect and anxiety symptoms (ps < 0.05), from pre-to post-training. No training-specific modulation emerged for positive affect and depressive symptoms. These findings provide a strong rationale for the use of frontal alpha asymmetry neurofeedback for the reduction of negative affect and anxiety in clinical settings.

https://www.ncbi.nlm...pubmed/25411662
Neurofeedback and Biofeedback for Mood and Anxiety Disorders: A Review of the Clinical Evidence and Guidelines – An Update [Internet].
Source
Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Aug.
CADTH Rapid Response Reports.
CONCLUSIONS AND IMPLICATIONS FOR DECISION OR POLICY MAKING
Similar to the original CADTH review, evidence regarding the use of biofeedback for treatment of post-traumatic stress disorder or depression came mostly from pilot and exploratory studies with preliminary analyses ranging in size from 11 to 100 participants. HRV biofeedback was commonly evaluated in the newer clinical trials, and it was found to be associated with improvement in PTSD symptoms and depression symptoms: in one systematic review of patients with posttraumatic stress disorder, HRV biofeedback therapy was not shown to be better than unspecified usual treatment, but in an observational study of depressive patients, it had statistically significant benefit over usual care (such as morning exercise and social activities). One RCT implied the possible clinical benefits of HRV biofeedback therapy over a sham control in patients with depression; however a statistically significant between-group difference was not detected in this small patient group. Furthermore, the clinical relevance of an observed between-group difference was uncertain due to the lack of minimal clinically important difference for the employed clinical scales. No evidence on the use of biofeedback or neurofeedback in patients with generalized anxiety disorder was identified. Compelling evidence from larger scale randomized controlled trials with alternative therapies as the comparator is still needed to confirm the potential of biofeedback and neurofeedback, and to develop guidelines regarding the use of these non-pharmacological and non-invasive modalities for the treatment of mood and anxiety disorders.
Several more research articles exist. Most are of small small size and conflicting results.

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#188 PrincessNutella

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Posted 28 December 2018 - 05:53 PM

I wish I had the chance. I read up on hydroxyzine comments, sounds good. Will get it tomorrow.

#189 fishinghat

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Posted 28 December 2018 - 05:55 PM

It is by prescription only here.


#190 PrincessNutella

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Posted 28 December 2018 - 06:02 PM

FH you didn't need to do that, thank you so much. I read all of these. I do breathing exercises. I use a magnesium supplement but will check on all electrolyte levels soon. And I benefited from phenylephrine + chlorphenamine maleate + paracetamol combo, but it makes me very drowsy. I can take that med in the evenings though, right?

#191 fishinghat

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Posted 28 December 2018 - 06:25 PM

Right. Hang in there Ozgun. Sorry, didn't mean to push. I just hate seeing anyone suffer.


#192 PrincessNutella

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Posted 29 December 2018 - 09:58 AM

You definitely did not push, FH.

I bought Atarax (25 mg) and an omega 3 supplement. Your recommended Atarax dosage with 25 mg Zoloft?

IUN, I thought about imbalances but I feel relatively better now. It might be my sodium levels as deficiency causes most of my symptoms.

#193 fishinghat

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Posted 29 December 2018 - 10:07 AM

I recommend 50 mg during the periods of high anxiety although I would start with 25 mg to see how it effects you. It may cause a little drowsiness when you first start it but that should fade. 50 mg at bedtime will help with sleep. Benzos interfere with REM sleep by hydroxyzine does not so the rest is more relaxing.


#194 PrincessNutella

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Posted 30 December 2018 - 07:53 AM

I had GI cramping today, ended up in ER. Any idea why?

#195 fishinghat

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Posted 30 December 2018 - 08:36 AM

No idea. Shouldn't of ate those jalapeño peppers. lol

#196 invalidusername

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Posted 30 December 2018 - 10:18 AM

Cramping as well? You poor thing. These things seem to seek you out. 

 

Wish I had some answers for you. Cramping can be a result of many things - could even be a simple reason to the stress of what you are currently going through with your study/work.


#197 PrincessNutella

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Posted 30 December 2018 - 11:30 AM

I wish it was those peppers FH :) I don’t want to blame it on Zoloft, but seems like it. When I reduced the dosage the symptoms diminished a bit.

#198 fishinghat

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Posted 30 December 2018 - 12:21 PM

Oh that's right. I forgot that you were on the Zoloft. Yea, it is famous for stomach issues. Not good for the effectiveness of your cross taper if that is the issue.

#199 gail

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Posted 30 December 2018 - 02:33 PM

Ozgun,

What did the ER say about this? Did they give you something for it.

I remember a few week back or so, you were saying that you having problems with constipation, has this been resolved? That can cause nasty and painful cramps!

#200 PrincessNutella

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Posted 30 December 2018 - 04:21 PM

The dude in ER advised me to change psychiatrists :) and they gave me a shot of Buscopan and Dramamine. I'm not constipated but my bowels still aren't that stable. As is my stomach. But better than when I was taking 50 mg of Zoloft.

#201 invalidusername

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Posted 30 December 2018 - 05:41 PM

Buscopan was prescribed for my GI issues on Cymbalta until Hat suggested it could be the reaction with the Celexa. He suggested I split the dose 12 hours apart - 4 days later - all gone.

 

Five weeks of of consistent diarrhea was no fun.

 

Still think your current stress levels will be exacerbating your current symptoms - and for that you have my every sympathy, dear Oz.


#202 gail

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Posted 31 December 2018 - 10:03 AM

Oz, are you serious that the dude suggested you change psychiatrist?

Got lost again, I thought that you were on Zoloft 50 ? Thanks for answering my first question by the way.

#203 PrincessNutella

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Posted 31 December 2018 - 06:33 PM

Gail, I was in serotonin hell with 50 mg so I reduced to 25 with better results. And he told me to change psychiatrists only if I was getting worse or not getting any better.

IUN, thanks. That shot of Buscopan and Dramamine got me back on my feet that day for lab work. I take it orally with no problems as well.

For the last 2 days I've been taking a protein pump inhibitor, got my nausea in order. I still think 25 mg of Zoloft is too much, though, but I'll try to stick with it for a few weeks.

#204 fishinghat

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Posted 31 December 2018 - 06:41 PM

Which PPI you taking Ozgun. Remember you aren't suppose to take Omeprazole (Prilosec) while taking a ssri/snri.

#205 PrincessNutella

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Posted 31 December 2018 - 06:45 PM

Only Omeprazole? Mine's pantoprazole.

#206 fishinghat

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Posted 31 December 2018 - 06:58 PM

Omeprazole is metabolized by the cytochrome P450 system in the live. This is the same system that reacts with ssri and snri so taking them together can allow dangerous levels of the antidepressant to build up in the blood stream.

Pantoprazole is metabolized mainly by demethylation by CYP2C19 followed by sulfation or by another metabolic pathway, oxidation by CYP3A4. Cymbalta does not interact with these two systems.

You are good to go.

#207 PrincessNutella

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Posted 31 December 2018 - 07:11 PM

Ah, great.

(I hated CYP's and never could memorize them, btw)

#208 invalidusername

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Posted 31 December 2018 - 07:57 PM

"Pantoprazole is metabolized mainly by demethylation by CYP2C19 followed by sulfation or by another metabolic pathway, oxidation by CYP3A4."

 

Er... exactly what I was going to say. :)


#209 fishinghat

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Posted 01 January 2019 - 09:08 AM

Ah, great.

(I hated CYP's and never could memorize them, btw)


One time when asked about his not knowing some physical constant Einstein said he didn't need to memorize this kind of data, that is why they made books.

#210 PrincessNutella

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Posted 02 January 2019 - 12:20 PM

Update: After having a panic attack, I thought I'd do better with 50 mg of Zoloft.
Psychological symptoms: Depression-anxiety swing. Getting better on the depression part.
Physical symptoms: Moderate nausea, feverish feeling, restlessness and tiredness at the same time.

I think my brain adapted. My body, on the other hand...



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