2 replies to this topic

[fishinghat]

http://www.jneurosci.org/content/32/47/16616.long

Anti-D lowers gaba

http://www.antidepressantsfacts.com/SSRIs-not-selective-GABA.htm

Anti-D raised gaba

http://www.ncbi.nlm.nih.gov/pubmed/15451391

Anti-D lowered gaba

http://ajp.psychiatryonline.org/article.aspx?articleid=175472

Anti-D raised gaba

 

[fishinghat]

Here are the articles and info on GABA crossing the blood brain barrier.                   

                                                   

GABA

The only way to deliver GABA effectively is to circumvent the blood-brain barrier. Indeed, there are a small, limited number of over-the-counter supplements that are derivatives of GABA, such as phenibut and picamilon combines niacin and GABA and crosses the blood–brain barrier as a prodrug that later hydrolyzes into GABA and niacin.

Phenibut

There are numerous reports of withdrawal symptoms on Internet forums and blogs  including "nervousness and shakiness, psychomotor agitation, feeling easily annoyed and irritated, fatigue, poor appetite, heart pounding and racing, nausea, insomnia, and feeling tense and keyed up", consistent with its GABA_B agonist properties. There has been no systematic study of this problem

http://www.ncbi.nlm.nih.gov/pubmed/23391959

http://www.ncbi.nlm.nih.gov/pubmed/21476277

http://www.ncbi.nlm.nih.gov/pubmed/20841974

http://www.ncbi.nlm.nih.gov/pubmed/19899708

http://www.ncbi.nlm.nih.gov/pubmed/19334514

http://www.ncbi.nlm.nih.gov/pubmed/18607733

 

Picamilon

Picamilon is able to cross the blood–brain barrier and then is hydrolyzed into GABA and niacin. The released GABA in theory would activate GABA receptors potentially producing an anxiolytic response. The second released component, niacin acts as a strong vasodilator, which might be useful for the treatment of migraine headaches.

Reported side effects include, but are not limited to, lightheadedness and decrease in blood pressure.

Phemibut has been researched more completely than picamilon. Neither are to be taken with benzos,

http://www.ncbi.nlm.nih.gov/pubmed/14558352

http://www.ncbi.nlm.nih.gov/pubmed/2736292

 

Here are the articles and info on GABA crossing the blood brain barrier.

[Wagtail]

I have bookmarked all the above to read later, I have an infected eye ATM so reading is hard.. Thank you fishinghat , as usual you have gone above & beyond for your forum friends ..:-))